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KMID : 0388220070140030268
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Journal of the Korean Rheumatism Association
2007 Volume.14 No. 3 p.268 ~ p.273
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Successful Treatment of Interstitial Pneumonitis Induced by Leflunomide
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Sheen Dong-Hyuk
Lim Mi-Kyung
Shim Seung-Cheol
Lee Sang-Ok
Lee You-Sun
Kang Sang-Ok
Song Joo-Kyung
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Abstract
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Leflunomide is a disease-modifying antirheumatic drug that has been available in Korea since 2003. Leflunomide induced interstitial pneumonitis has been reported as an adverse effect in other countries but not in Korea. A 57-year-old woman was treated with leflunomide since she had been resistant to methotrexate, hydroxychloroquine and sulfasalazine. She developed high fever, dyspnea, and non-productive cough 3 months after the administration of leflunomide. She was diagnosed leflunomide-induced interstitial pneumonitis based on history, physical, laboratory, radiologic and pathologic findings. The patient was treated by prednisolone 1 mg/kg/day with cholestyramine 24 g/day, resulting in dramatic improvement. Here we report a case of leflunomide induced pneumonitis treated successfully with high dose steroid
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KEYWORD
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Leflunomide, Interstitial pneumonitis, Rheumatoid arthritis
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